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For successful bone regeneration tissue engineered bone constructs combining both aspects, namely a high osteogenic potential and a rapid connection to the vascular network are needed.
For tissue-engineered bone formation, autogenous osteogenic cells are of paramount importance for successful bone formation.
A suitable biophysical environment was predicted for successful bone healing.
Our goal was to find the most favorable conditions for successful bone grafting.
Thus, it can be concluded that angiogenesis is essential for successful bone grafting.
In support of this, one report in 1996 [18] proposed several requirements for successful bone grafts.
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For the successful bone graft procedure, timely degradation of the graft is essential for new bone regeneration.
MSCs colonization of scaffold favors vascularization of the implant, which is essential for the successful bone prosthesis.
A balanced immune response appears to be essential for a successful bone healing process (Kolar et al. 2010; Schmidt-Bleek et al. 2012a; Schmidt-Bleek et al. 2012b) - and this balance, so far, is best achieved in the haematoma ensuing upon injury.
The donor site of autologous bone is also a major consideration for successful autologous bone grafting, and affects the long-term resorption rates of grafted bones and implant success rates.
A clear understanding of complex ankle anatomy and morphology is essential for successful talar bone replacement.
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CEO of Professional Science Editing for Scientists @ prosciediting.com