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Oct4 contains two distinct DNA binding domains (the POUH and POUS domains, each of which can bind to half of the DNA octamer motif independently of the other) which are separated by a flexible linker [39]; this in turn allows for substantial leeway in arrangement of these domains in relation to each other [17].
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How did the Giants' salary cap become so tight, when other teams seem to have substantial leeway?
In general, Americans were willing to give the government substantial leeway in dealing with foreigners suspected of terrorism.
But they clearly believe the public is so angry and so alarmed by the terrorist attacks that they will grant substantial leeway to the executive branch.
The World Trade Organization requires all countries to grant 20-year patents on medicine, but gives nations substantial leeway over which specific drugs actually receive patents.
This attribute portends that the use of [99mTc]tilmanocept provides substantial leeway and scheduling flexibility with regard to time of injection and subsequent lymphoscintigraphy and SLNB procedures (i.e. next-day surgery) without compromising the reliability of results.
Netflix itself is poised for substantial growth.
The musicians must memorize the work, which allows for considerable leeway in detail and duration.
State officials have long asked for more leeway to impose such charges.
But as we are in London we are hoping for some leeway.
The Copyright Act allows for some leeway when a work is used for certain purposes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com