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CACO helps to locate good initial fuzzy systems for subsequent phase learning.
This clinical and biological data will aid in sample size projections for subsequent phase 2b/3 clinical trials.
Oral dosing regimen selected for subsequent Phase II/III clinical trials was 60 mg of PHFST, b.i.d., and dose up to 120 mg, b.i.d.
In a phase I trial of a novel ER-targeting therapeutic (i.e. GDC0810), 18F FES was also used to monitor in-vivo drug binding and successfully assess the appropriate dose for subsequent phase II trials (Wang et al., 2016).
Aromatic hydroxylation reactions, which are mainly catalyzed by cytochrome P450 (CYP) enzymes in vivo, are some of the most important reactions of Phase I metabolism, because insertion of a hydroxyl group into a lipophilic drug compound increases its hydrophilicity and prepares it for subsequent Phase II metabolic conjugation reactions as a prerequisite to excretion.
The aim was to identify targets for subsequent phase I, II and III trials.
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By employing the benchmarking process during the course of the project, industry practitioners can improve project performance and develop proactive strategies for subsequent phases.
Clark et al. (2011) elaborate on these SURGE Classic design approaches in greater detail, but the descriptions here are sufficient to ground our discussion of the implications of lessons learned from SURGE Classic for subsequent phases of our game design, as well as for games for science learning more generally.
It is looking at current post-conflict housing issues in hosting countries with a focus on Syrian refugees in Sweden, and it depicts a phase of the project where a foundation for subsequent phases – including constructing a physical house prototype through involving refugees in a construction training – was laid.
They also tabled a simplified proposal for subsequent phase-down steps that replaces competing offerings from the North American countries and the European Union. .
A growing body of evidence supports the idea that removing grazers decreases the resilience of a reef ecosystem, thereby reducing its ability to withstand a phase-shift from a coral to an algal-dominated state as well as decreasing the potential for subsequent phase-shift reversals [32].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com