Sentence examples for for subsequent degradation from inspiring English sources

The sample was then reused for subsequent degradation.

These results indicate that USP7 is dispensible for arsenic-induced SUMOylation of PML but is important for subsequent degradation of these modified isoforms.

The HCMV US2 protein, which like the US11 protein, dislocates class I heavy chain molecules into the cytosol for subsequent degradation by proteasomes [39], was less effective in the hMSCs.

For example, endocytosis of receptor tyrosine kinases (RTKs) requires tyrosine phosphorylation and monoubiquitination of the receptor and downstream components to sort endocytosed cargo for subsequent degradation (down regulation) or recycling to the cell surface [2], [3], [4].

However, when present in the nucleus, Foxo1, Foxo3 and Foxo4 can induce the transcription of the two muscle-specific ubiquitin ligases, MAFbx/atrogin-1 and MuRF1, which are thought responsible for the specific targeting of proteins for subsequent degradation by the proteasome [7], [8].

These so-called autophagosomes deliver cytoplasmic material to the lysosome for subsequent degradation.

The APC/C is responsible for ubiquitinating critical cell-cycle regulatory proteins, targeting them for their subsequent degradation by the 26S proteasome (reviewed in McLean et al. 2011; Primorac and Musacchio 2013; Teixeira and Reed 2013).

We next examined whether parkin is able to ubiquitinate p62 for its subsequent degradation.

These data demonstrate that the ubiquitination of p62 is specifically mediated by parkin, while the disease causing mutants that have impaired E3 ligase activity fail to ubiquiniate p62 for its subsequent degradation (Fig. 5F).

Also, the values of A, E*, ΔH* and ΔG* increase for the subsequent degradation steps, revealing the high stability of the remaining part as well as the lower rate of the removal of the subsequent species than that of the precedent one [22].

The down-regulation is likely due to the degradation of this protein because NDRG1 strongly increased phosphorylation of β-catenin at Ser33/Ser37/Thr41 residues that are the targets of GSK3β for the subsequent degradation of β-catenin (Supporting Information Fig S1F).