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Another advantage of the Reilhac implementation is that it can also be used for static scans, which is not the case with HYPR.
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The optimal time interval for static scanning is set at 40 to 60 min after tracer injection.
Qualitative and semiquantitative interpretation of static scans is probably sufficient for routine clinical staging purposes.
Tumor volume from static scan is useful in NPC prognosis.
Whole-body PET data was acquired by performing static scans for each animal at 24 h post-injection (p.i).
Thus, it is possible to substitute SUV analysis derived from a few static scans for the complete dynamic scan when scanner time is limited.
The DQA protocol calls for a static scan using a 57Co flood phantom placed as close as possible to the LEHR collimators, per manufacturer's recommendations.
PET data for each mouse were recorded via static scans at various time points between 6 and 120 h.
For PET imaging, the mice were i.v. injected with 11.1 MBq Cu-cyclam-RAFT-c -RGDfK- 4, and at the indiCu-cyclam-RAFT-c -RGDfK- 4p.i.,), statiCu-cyclam-RAFT-c -RGDfK- 430 min using a small-animal PET system (Inveon; Siemens MediCu-cyclam-RAFT-c -RGDfK- 4alvern, PA) with the animals under 1 % isoflurane anesthesia.
Paired comparisons between Patlak-like and SUV m slopes showed good agreement by both linear regression and correlation coefficient analysis (r = 84%, r s = 78%-SUVmax, r = 92%, and r s = 91%-SUVmean), suggesting static scans could substitute for dynamic studies.
Thus, the need for doing dynamic scanning followed by several static scans over a prolonged period of time with PET techniques could prove a disincentive for patients.
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