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Exploring scenarios for specificities of 0.98 or 0.99, and sensitivities varying between 0.7 and 0.9, leads to the conclusion that the observed heritability is possibly underestimated by 20 to 40%.
This may account for specificities mentioned above.
Antibodies detected on the arrays were then examined for specificities appearing in HC that were lupus-like.
Additionally, PCR products were digested with restriction enzymes Hha I, Mbo II and Hae III (see Additional file 5 for specificities).
Although the sequence sets used for testing are limited, their sensitivities are clearly below 90% for specificities estimated to be close to 90%.
Because the specificities relate to the negative subjects, when the prevalence is low, there are more truly negative subjects who provide more experimental information for specificities than for sensitivities; thus, the more precise posteriori estimates of specificities are obtained.
Similar(49)
Several species-specific target sequences were evaluated for specificity.
Primers and hybridisation probes specific for the IAC were designed and assessed for specificity.
Lacassagne had his own knack for specificity.
His agenda should be given points for specificity.
But that search for specificity and reliability only makes the problem worse.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com