The c indices for the specific validation cohorts were 0.62, 0.65 and 0.60 for the Gerestein, Chi and Teramukai model, respectively.
Furthermore there is need for region specific validation of CD4 and TLC counts changes both "Pre-HAART" and on HAART.
For a specific validation of the model, the estimated decrease in incidence due to annual FOBT screening was found to be almost equal to benchmark data from 18-year follow up of the randomized controlled trial after adjustment for the period during the trial when screening was temporarily halted, as well as adjustment for compliance [ 36].
Due to differences in criterion methods there are limitations concerning comparability of studies since the doubly labeled water method used for validation of daily energy expenditure [ 11, 12, 30] does not allow for the activity specific validation attended in the current study design.
Since the tasks performed were the same as those reported and validated in the LASTT model [11, 12, 13] and since this new model is basically the same, except for the design, a specific validation was not necessary.
All records are controlled for general inadequacies and specific validation studies indicate that coverage is above 98% and that almost 90% of the diagnoses reported to the inpatient register are correct when compared with the original medical files[11].
The scales have specific validation for MS and can be used on patients of any age, sex, and duration.
The scales have specific validation for stroke and can be used on patients of, amongst other factors, any age, or sex.
The Validation/Clinical Studies (VCS) Core has identified specific validation guidelines for each of the levels.
The 480 proteins from the iTRAQ study with fold change above +/− log2 (0.58) in this analysis does however need further verification in different sample sets, by different methods or specific validation by for example selective reaction monitoring to increase the certainty of these findings.
These preliminary results also make clear that perhaps specific validation is needed for classification criteria outside the Western world.
