This study employs multiple functions for nanotherapeutic treatment of specific target cells, i.e. cell-specific targeting, controlled cellular endocytosis and magnetic-responsive intracellular drug release.
Synthetic Aptamer-Polymer Hybrid Constructs for Programmed Drug Delivery into Specific Target Cells.
By delivering cDNAs that code for therapeutic proteins to specific target cells, the genetically modified cell is converted to a biofactory for protein production [ 66, 122, 123].
Viral vectors can be used to deliver cDNAs that code for therapeutic proteins to specific target cells, and the genetically modified cell is converted in a biofactory for protein production [ 18].
Oh, S. S. et al. Synthetic aptamer-polymer hybrid constructs for programmed drug delivery into specific target cells.
In this study we used our MCMV infection model and a multi-color flow cytometry approach to quantify the effect of MCMV on the developing brain, identifying specific target cells for viral infection and its effect on subsequent brain development.
Recently developed conditional knockout models for XOR that are based on CRE/Lox technology may be of particular value for the knockdown of XOR in specific target cells, such as hepatocytes or adipocytes, that are principal sources of SUA[137].
After washing, 2×104 DCs were cultured with 1×105 purified, allogeneic CD8 T cell along with 1×104 irradiated PC3 (American Type Culture Collection, Manassas, VA) cells for 10 days to generate PC3 specific target cells.
Whatever the underlying cause, the observed difference between distinct herpesviral immune evasion proteins in their capacity to suppress MHC class I expression on the surface of hMSCs argues for the screening of different immunoevasins for each specific target cell type, donor and application.
TCCs that reacted positively to CaPo13 were re-tested for their ability to recognize the specific target cell line CaPo13 and not the non-specific melanoma cell line LB-40 or the NK specific cell line K562.
