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Protocols could be developed for specific indications and regions of the body.
Nonetheless, there are uncertainties regarding the effectiveness and associated mechanism of action of autologous therapies for specific indications (Sheth 2012).
This raises the interest to improve PET/MRI protocols for specific indications taking into account organ and pathology dependent adaptations [11],[11].
Except for specific indications such as tumor lysis syndrome, the indications for RRT are similar to those in the general ICU population.
Regulatory requirements are typically published in standard 'Guidance documents', but in practice the 'one size fits all' approach has room for interpretation for specific indications and clinical trials.
Morphological T1-weighted TSE black blood sequences were added to the above protocol only for specific indications (e.g. morphology assessment and tissue characterisation in suspected arrhythmogenic right ventricular cardiomyopathy [ARVC]).
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Additionally all guidelines containing recommendation on clinical trials for specific indication have to be carefully scrutinized and updated in respect to the requirements for conducting clinical trials in the paediatric population taking into account the different age groups [ 9].
Only adult patients were included because the drugs selected in the analysis are indicated for adults (and are given exceptionally to children for very specific indications).
Other imaging techniques, like MRI with MR-cholangiopancreatogaphy (MRCP) sequences and fluoroscopy, are less useful and are used mainly for few specific indications [4].
Despite this, they remain the treatment of choice for some specific indications.
In cases where a given risk factor works in different directions for the specific indications, we might expect less clarity and uniformity with regard to overall revision.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com