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Selected cells for specific expression were treated with erlotinib, genistein, gemcitabine, or the combination.
This definition emphasizes that regulatory sequences as well as coding regions are required for "specific expression".
It has been reported that the integration of AaIT into M. anisopliae for specific expression in the insect hemolymph after cuticle penetration resulted in 22-, 9-, and 16-fold increases in fungal toxicity to the tobacco hornworm Manduca sexta, the yellow fever mosquito Aedes aegypti, and the coffee berry borer Hypothenemus hampei, respectively (Pava-Ripoll et al. 2008; Wang and St Leger 2007).
Our experiments indicate that AAV2 vectors carrying the GFAP promoter are a promising tool for specific expression of transgenes in activated glial cells.
This suggests that these two sites are necessary both for basal expression (in any cell type) and for specific expression in endothelial cells.
For example, the early growth response gene 1 (egr-1) enhancer/promoter, has been used as a regulatable promoter for specific expression of HSV-TK in glioma cells and can be induced by radiation [10].
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The APO E enhancer is usually used in combination with the hAAT promoter for liver specific expression for factor IX in gene therapy [ 30, 31].
Some of her prior work centers around mathematical modeling and Bayesian models for allele specific expression.
This suggests a significant change for tissue specific expression.
This is particularly valuable for searching specific expression patterns of interest.
These reasons have led to utilization of the Cox-2 promoter as a tumor specific promoter for cancer specific expression [15] [20].
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