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Limitations include few current smokers in both the 27K and the 450K data set and use of self-reporting for smoking information, which is usually reliable although sometimes underreported (Wagenknecht et al. 1992).
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For example, some smoking information is available in the Medical Birth Register, but not in the Patient Register.
During this process, 6% of the sample for whom no smoking information was available were excluded and the base population estimate was reduced by 10% because information on only 90% of deaths was available.
On this basis, 19 158 women (19 049 with history of hysterectomy, 109 with a history of endometrial cancer) were excluded, as were 86 women for whom no smoking information was available, and follow-up was based on the cohort of 70 591 women with intact uteri and with no history of endometrial cancer.
A possible explanation for this is that smoking information was subject to misclassification (the smoking information for cases was mainly from next-ofkin) and potentially resulting in imperfect adjustment and residual cofounding by smoking.
As a result, our smoking information for a child's exposure can only be dichotomized as yes versus unknown.
Of 859 cases and 3193 potentially eligible controls, 353 cases and 724 controls were available for interview and provided smoking information including menthol status.
In general, smoking information for cohort members is only available since 1971, when standardised and well-recorded medical check-ups were introduced.
Women who reported being non-smokers in either the early or mid pregnancy periods but were missing smoking information for the previous time period(s) (n = 24 and n = 72, respectively), were categorized with former smokers for that previous period in order to preserve a reference group of confirmed non-smokers who did not smoke in any prior pregnancy period.
The selection of 1998 2000 data for these exposure-outcome analyses was due to missing smoking information at baseline for RHINE and I-ECRHS.
Smoking information was missing for 10 cases and for seven controls.
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