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The development of an evaluation method for site accessibility.
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For example, Xu et al. [ 48] observe that a certain normalized measure of site accessibility, has a characteristic pattern around the target site region.
In an elegant study on the rules determining global nucleosome positioning in yeast, Segal et al. found low nucleosome occupancy at TSS and examined frequencies of TFs for the occurrence of nucleosome occupancy: the yeast NF-Y homologues HAP2/3/5 came on top of the ranking for binding site accessibility by intrinsic nucleosome positioning [48].
miRU [ 33], the first tool for the plant-specific miRNA target prediction, which was later upgraded to psRNATarget [ 34], uses a dynamic programming approach, aligning sequences using a modified Smith-Waterman algorithm and applying the 'RNAup' algorithm [ 35] for target site accessibility.
The results of this study indicate that there is a maximum amount of mesopore volume required for optimal acid site accessibility leading to increased bio-oil production.
(c) Corresponding differential site accessibility for the four different guest molecules on r2KCHA.
VRMs and VRBs were used to determine target site accessibility for siRNAs designed against the HCV genome.
Insertion of Ag nanoparticles into the interlayers between graphene sheets reduced the mean number of graphene stacking layers in the composite and provided a better site accessibility for Li+ insertion.
α-Pinene exhibits a volcano dependence on HPW loading over the SBA-15 support due to competition between the number and accessibility of acid sites to the non-polar reactant, with the superior acid site accessibility for HPW/SBA-15 conferring a 10-fold rate enhancement with respect to HPW/fumed silica and pure HPW.
A method for testing the active site accessibility of resid cracking catalysts has been developed on currently widely used MAT equipped with the unstripped hydrocarbon burned off in place, with an online measurement of the CO2 and H2O that are produced.
This procedure is time-consuming and yields only moderate amounts of useful product owing low capacity and poor site accessibility for the template molecules because the grinding process may be detrimental to some of the binding sites.
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