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In comparison to non-structured UTRs, a correlation-based search for similar expression pairs (using ) results in slightly more correlated expressed pairs between transcripts coding for RNA binding proteins and transcripts with structured UTRs.
Having established the expression of BCAS3 in glioma cell lines in vitro, we looked for similar expression in brain tumor tissue and wall of brain abscess rich in vasculature (Table 1).
The selected groups of genes were again organized for similar expression patterns using Euclidean distance and hierarchical clustering with the average linkage clustering method of JCVI MEV (see Materials and Methods).
Genes were grouped based on their expression vectors using the k-means algorithm, and selected groups of interest were again organized for similar expression
MiRNAs clustered together for similar expression patterns [ 37].
As with SMAD4, we used IDH2 as a prototype to look for similar expression profiles.
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Results: To enable better cross-species comparisons, we developed methods for automatically identifying pairs of similar expression datasets across species.
For a receptor to be of interest for targeting, similar expression in both the primary tumors and the disseminated lesions are required.
BLASTN-searches demonstrated strongly different expression intensities for the homologous GPx genes in the two Selaginella haplotypes, for which similar expression intensities of APx and Prx genes were shown (Table 1).
Both hsa-mir-143 and hsa-mir-145 are encoded by the same gene, which accounts for their similar expression profile.
While the predominantly epithelial and epithelial-derived cellular expression of mammalian s100 genes is maintained in zebrafish, the actual regulatory mechanisms responsible for this similar expression may be different.
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