The acute consequence of inhalation of Zn dust is zinc fever; however, for severe effects (deaths), the concentration needs to surpass widely the permissible exposure limit of 5 mg/m3 CNT Low High n.a.a
Although these statistical analyses further support the role of steroidal estrogens in the causation of feminization of wild fish in U.K. rivers, they also suggest that antiandrogens are strong causal factors, necessary for severe effects to occur.
Moreover, using multiple-gene knockout data, we find that functional compensation by duplicate genes for a more severe phenotypic effect tends to be preserved by natural selection for a longer time than that for a less severe effect.
However, the possible pathogenic mechanism for the more severe effect on enamel seen in patient 2 remains unclear.
The importance of WC-2 for interaction of WC-1 with FRQ [ 86] may be one reason for the more severe effect on transcriptional regulation that we observed in the Δ wc-2 mutant.
Surprisingly, only the G1976 mutation dramatically altered the rate of exon inclusion in the splicing assay (figures 2, 3 and table 1), while the A1963G mutation, which should have been responsible for the most severe effect on splicing, according to both ESEfinder and RescueESE, instead caused an increase in the exon inclusion rate.
Differences between groups were seen in the severity of side effects with a tendency for less severe effects in the NT group (table 4).
Additionally, increasing the number of partitions have a more severe effect for RUS due to the lack of data.
The primary aim of this study was to identify protein toxins responsible for the severe effects of C. fleckeri stings in humans.
Because the fetus cannot metabolize organophosphate chemicals as well as its adult mother can (Chen et al. 2003; Furlong et al. 2006), there is a compelling biological basis for more severe effects once the compound passes through the placenta.
