Two different procedures, or algorithms, have previously been proposed for the production of sequential actions (Houghton and Hartley, 1995).
A particular convincing example for the sequential action of two cytokines was observed after activation of NK cells by ligands of TLR3, TLR4, TLR7 or TLR9, which was strictly dependent on IFN-α/β signaling as well as IL-15.
Tf can reach the lysosome-like parasitophorous vacuoles where Leishmania resides in macrophages, but it appears to function mainly as a source of Fe3+ for the sequential action of two surface-associated parasite molecules: the Fe3+ reductase LFR1 and the LIT1 transporter, which directly promote Fe2+ uptake.
Evidence for a sequential action of PKA and p38 MAPK within the same pathway has been found in various cell types, where PKA has been proposed to activate p38 MAPK through an as yet unknown mechanism (Zheng et al., 2000; Delghandi et al., 2005; Shi et al., 2006).
The precise contribution of the basal ganglia to motor learning remains unclear but one consistent finding is that they are necessary for early acquisition of novel sequential actions.
Haem (iron protoporphyrin IX) is both an essential growth factor and virulence regulator for the periodontal pathogen Porphyromonas gingivalis, which acquires it mainly from haemoglobin via the sequential actions of the R- and K-specific gingipain proteases.
Sequential actions of these two RNA polymerases are thought to be essential for chloroplast differentiation.
PGE2 is synthesized from arachidonic acid by the sequential actions of phospholipases, cyclooxygenases, and PGE synthases.
The sequential actions of experiencing, questioning, analyzing, adapting, envisioning, and reflecting on MEAs as a vehicle for STEM integration in mathematics classrooms will inform additional iterations of professional development that is tailored to the context and readiness of its recipients.
For example, the sequential action of ath-miR156 (ath-, Arabidopsis thaliana) and ath-miR172, which leads to repression of SMZ, SNZ, TOE1 and TOE2, regulates flowering in Arabidopsis [14], [15].
