Exact(3)
Expression data for selected kinases were presented by heatmaps.
Figure 4 figure supplement 2 shows full Michaelis Menten curves for selected kinases and DFGx mutants.
Using chemical inhibitors for selected kinases we show that mitogen activated protein kinase- and phosphoinositide 3 kinase-signalling are dominantly involved in regulating genes included in the αIgM gene module.
Similar(57)
The dose response curves for selected kinase inhibitors are shown in Figure 4.
Moreover, even when we introduced a bias for selecting kinases and phosphatases, only 57% of resulting proteins belong to this class, when initially 68% were present in the library.
On the other hand Type I drugs are less selective and show binding preferences for both the open and closed forms of selected kinases.
To be more precise there has to be a pIC50 value for each of the selected kinases.
A number of compounds were chosen for IC50 determinations against selected kinases (Table 1).
Red boxes indicate pairs of kinases used for PCC analysis, gray color indicates the genes without probes in affymetrix array platform, and asterisks indicate the selected kinases.
Therefore, users can easily estimate the functional redundancy between closely linked family members for the selected kinase.
For each selected kinase, the associated ontology data was collected using the ProKinO browser (http://vulcan.cs.uga.edu/prokino) and cross-checked with the appropriate parent sources.
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