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"We should prepare psychologically and economically for reversion to the status of a normal nation".
I have always been impressed by the inexorable tendency for reversion to the mean in security returns.
The lack of productive viral replication further improves the safety profile of MVA as a vector, minimizing the potential for reversion to virulent forms particularly if used in immunocompromised individuals.
However, one hurdle for developing successful live-attenuated vaccines lies with the viral RNA-dependent-RNA-polymerase (RdRP) enzyme whose low replication fidelity allows for reversion of attenuated viruses to disease causing variants.
The free energy penalty for this disruption may provide a driving force for reversion back to the original (undeformed) state of order and, correspondingly, a large amount of local chain relaxation.
For reversion, the βme (5 mM) and the Gly-Gly-His peptide (2 mM) were used.
We do not allow for reversion of resistant strains to wild type in the absence of ongoing selective pressure from antiviral drugs.
Similar(4)
The magnitude of fitness recoveries is larger for reversions than for compensatory mutations; therefore, we could expect reversion to be the preponderant mutation type in reverse evolution experiments.
Because EWD8 cells have luminal parentage [ 22], we looked for reversions by using ER and PR as markers.
Possible explanations for reversions include clearing of TB infection, biological variation in interferon gamma levels, or variability in laboratory and test procedures.
Thus, although Blimp1 is obligatory for PGC specification, it is not required for the reversion of epiSCs to ESCs and for their maintenance thereafter.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com