Weir's slump has been a depressing narrative for him to repeat week after week.
For repeated IgG treatment, female 8-week-old C57BL/6J mice (n = 7/group) were maintained as described earlier.
Given the schedule dependency observed preclinically, three regimens were explored in phase I studies: (1) 0.2–5.2 mg m−2 daily for 5 days every 3 weeks (McDonald et al, 1998); (2) 10 40 mg m−2 weekly for 4 weeks repeated every 6 weeks (Rinaldi et al, 1995); and (3) 50–700 mg m−2 every 3 weeks (Rinaldi et al, 1999).
Scans for tumor assessment are repeated 2 weeks after the fourth treatment dose (week 12) and in 12 weeks (week 24) and every 3 months thereafter.
The obvious place to launch it is the Super Bowl, where the ads are not only seen by millions, but also pored over and repeated for weeks afterwards.
What was different was that combat was confined to battlefields that at their biggest were about three and a half miles wide, and that the slaughter usually ended at sunset, not to be repeated for weeks, months, or years.
Treatments were repeated every week for three consecutive weeks followed by one week of rest; a full cycle consisted of four weeks.
Patient screening was designated for one day each week and was repeated for 8 weeks.
All patients were randomly assigned to the two treatment groups: IFNα2b 20 MU/d2 /d IV 5 days/week × 4 weeks, repeated for three times on weeks 9 to 12, 17 to 20, 25 to 28 (Dose-Dense/Dose-Intense, DD/DI, arm), or IFNα2b 20 MU/d2 /d IV 5 days/week × 4 weeks followed by 10 MU/m2 SC three times per week × 48 weeks (High Dose Interferon, HDI, arm).
To ensure robust experimental replication and manageable workloads, we employed a staggered honey bee collection scheme, which was repeated every week for a total of five weeks.
