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The sum of the main indices (revealing the individual effect of factors) of epidemic intensity, landscape connectivity and choice of R gene accounted for 82% of the variance for relative damage.
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Epidemic intensity, landscape connectivity, and choice of the R gene together accounted for 78% of the variance for the relative damage obtained with constant-mixture sustainable strategies (CSS).
However, for higher epidemic intensities, relative damage increased steeply, whatever the resistance gene.
Despite this simplicity, interactions between within-host and between-host processes accounted for 8%and13%3% of the relative damage obtained with CYS and CSS, respectively.
When two mutations are required, high levels of disease control (i.e. relative damage < 10%) were achieved for the entire range of epidemic intensities explored.
I asked about the relative damage done by Abu Ghraib and by Guantanamo.
For both fitness costs, VYS provided substantial additional benefit (mean of 11%; highest value 16%) when the relative damage of CYS was >10% (Table S2).
In situations in which within-field infections predominated, relative damages for CSS were always 100% for epidemic intensities >0.6 (Fig. 4A).
It defined thresholds for epidemic intensity below which relative damages were identical for both strategies (i.e., the solid and dashed lines merge in Fig. 4).
When a margin of improvement exists for CYS (typically when their relative damages are >10%), the mean additional relative benefit was 8% and the highest values (up to 18%) were observed for intermediate epidemic intensities (Table S2).
These sensors are suitable for detecting relative DNA damage rates in <5 min of the enzyme reactions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com