This is suggestive of related functions for LNX2 and MUPP1 in this context.
New combined MR-PET approaches for relating function to ligand receptor interactions may elucidate these mechanisms in vivo, adding depth to the PET-based interrogation of the rich biology of the synapse.
These and our own results therefore strongly support the 'RNA operon/regulon model', which suggests the coordinate cis-/trans-regulation of multiple mRNAs coding for proteins with related functions [37], [38].
Targets of WT1 are statistically enriched for cancer related functions including metastasis and apoptosis.
Genes in the THYM cluster are enriched for the related functions immune system and lymphatic system development, cell death, and cellular growth and proliferation (Table 3).
Intriguingly, miR-15 is found most significant for its targets non-coherence, especially for signal transduction related functions in mouse development (Table S17) while target gene acvr2 is coherent to miR-15 consistent with that in [44].
Semantic similarity is a powerful technique for clustering putatively related functions, but is not necessarily an appropriate method for retrieving exact annotation as this strictly depends on the cut-off, the graph structure and the measure used [15], [21], [35].
Several new inequalities are given for these and related functions.
"Neuronal" kinase genes were associated to GO-terms nervous system development & differentiation and synaptic function whereas example kinase genes associating to these processes were PRKCE [23] and EPHA4 [67], both known for nervous system related functions.
These target genes are already experimentally validated for potential ovary related functions in different mammalian species (references in additional file 3).
