Patients with eGFR <30 mL/min/1.73 m were excluded; therefore, the study cannot address the safety issues for this group, for whom reduced clearance of fenofibrate and its metabolites has been reported (39).
Thijssen et al. showed patients with the *1/*3 genotype had mean oral clearance rate that was 45% lower than the wildtype for acenocoumarol [ 21], and Ufer et al. reported 51%and29%9% reduce clearance rates, respectively, for *2 and *3 for phenprocoumon [ 22].
Besides, reduced clearance rates were found for the same hrHPV types as found by a negative RLB result, that is, HPV16, HPV18, HPV31, and HPV33.
Kp-10 was found to significantly reduce clearance, in keeping with decreased blood flow and providing further evidence for vasoconstrictor activity.
Reduced clearance allows the use of lighter-grade oil.
Recycling and clearance are options for reducing the volume of radioactive waste in a fusion power plant.
Alsius sells in Europe and just received clearance in the United States for reducing fever in stroke patients, but not for cooling below normal.
Animals infused with casein had increased arterial concentrations of AA, increased mammary extraction of AA from plasma, either no change or a trend for reduced mammary AA clearance rates, and no change in milk protein yield.
While there certainly is evidence for reduced hepatic drug clearance in humans and rodents, the possibility that this is caused by reduced P450 activity is controversial [ 44].
We sought to distinguish clearance from adsorption as the principal mechanism responsible for reducing circulating IL-6 levels with hemofiltration.
