Thus, the elevated levels of NT-proBNP and the associated increased risk for mortality in this setting could not entirely be accounted for by reduced clearance of the marker.
This allows for a reduced clearance function and promotes secondary bacterial pneumonia [ 15].
Also, autophagy defects in ESCRT mutants have been associated with reduced clearance of protein aggregates typical for neurodegenerative diseases, and mutations in Vps2/CHMP2B were described in patients with hereditary forms of amyotropic lateral sclerosis and fronto-temporal dementia.
This was associated with reduced clearance and increased toxicity from docetaxel, a well-characterised substrate for CYP3A4.
This was associated with reduced clearance and increased toxicity from docetaxel, a well-characterized substrate for CYP3A4 [ 14, 15].
There are also the potential confounding factors to account for which are present in CKD, being a chronic inflammatory condition, and resulting in reduced clearance of adipokines [ 29].
The Mabs form a complex with IL-6, which results in reduced clearance of the cytokine.
There is also excess formation and accumulation of AGEs due to reduced clearance of these macromolecules.
In addition, the special coating (pegylation) of the liposomes is associated with reduced clearance by the mononuclear phagocyte system, thus helping to maintain active drug concentrations for longer periods [ 10- 13].
They acknowledged, however, that there are other potential explanations for reduced MMAAP clearance, such as hypoxia and reduced protein synthesis during critical illness as well as competitive metabolism with concomitantly administered drugs.
For example, dosimetric studies show reduced clearance of PM in all regions of the respiratory tract with increasing age beyond young adulthood (U.S. EPA 2009).
