Sentence examples for for redirected from inspiring English sources

Novel antibody-vaccine engineered constructs (AVEC) create the solid foundation for redirected, accelerated, and amplified prophylactic, HBV vaccination-induced immunity immunotherapy (RAAVIIT) of ovarian cancers.

Similar safety concerns may delay or hinder development of bispecific antibodies where an anti-CD3 binding domain is paired with antibody domains against a tumor-associated antigen for redirected tumor killing by cytotoxic T cells.

For redirected trogocytosis, experiments were performed as described previously [32], but using HEK cells stably transfected for the expression of FcγRII instead of P815 cells.

This will fully activate T cells for redirected lysis involving production of granzyme B, proliferation, and adoption of a serial lysis mode [34] [36].

The highly sub-saturating amounts of BiTE antibody as used for redirected lysis are moreover unlikely to modulate signaling activity of the target in a meaningful way.

The presence of human PBMCs at an E T ratio of 2∶1 in subcutaneous tumors, as is needed by MT110 for redirected lysis in immunodeficient mice, did not significantly retard or reduce tumor growth.

Novel Bispecific T-cell Engager (BiTE; Micromet, Munich, Germany) antibodies are designed to transiently connect T cells with cancer cells for initiation of redirected target cell lysis.

While the manufacturer says it reduces radiation more than 60 percent, some electrical engineering experts question whether the case may have the opposite effect at orientations where your head is in the way of the cell tower because your phone may have to increase its transmission strength somewhat to compensate for the redirected signal.

However, in light of safety issues, UniCARs comprising a CD137-CD3ζ CD137-CD3ζdomain emerged asignalingcts of choice for a clinical application of redomainemergeds.

For the GFP-tagged proteins tested, the pattern of capture by OT-I T cells was very comparable to what was found in the case of redirected trogocytosis, as shown for representative examples of proteins transferred either efficiently (CD9), or moderately (CXCR5) or not at all (MeCP2) (Figure 4B, and data not shown).

Moreover, a co-stimulatory signal for bsAb-redirected and -activated T cells does not necessarily have to be mediated by interaction with the target cells.