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The plasma curcumin concentration was much higher for pulmonary administration than for oral administration.
The objective of this study was to understand the spray drying process of insulin intended for pulmonary administration.
However, despite the success of using an inhaler for pulmonary administration, similar side effects still remain for ICS, especially when the doses are escalated.
In this study, we developed a new formulation using an innovative controlled delivery system for resveratrol: s dry powder inhaler form designed for pulmonary administration.
The approach used here enabled the generation of a thermostable, antigenic WIV vaccine powder with desired physical characteristics that could be potentially used for pulmonary administration.
The area under the plasma concentration time curve per dose for pulmonary administration of the 1 4 and 1 10 PLH-MAN microparticles was approximately 85- and 100-fold higher, respectively, than for oral administration of PLH powder.
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The curcumin concentration decrease from the plasma appeared for the pulmonary administration to be in two distinct phases with an initial rapid elimination occurring in the first hour followed by a slower elimination from 1 to 8 h.
Nevertheless, delivery of nano-based drugs via pulmonary administration for lung cancer therapy is still in its infancy and numerous challenges are expected.
For direct intramacrophagic antitubercular therapy, pulmonary administration through Dry Powder Inhaler (DPI) devices is a reasonable option.
Milrinone pulmonary administration is used currently for the treatment of pulmonary hypertension.
Moreover, Cpd #15 proved to be suitable for pulmonary topical administration given its sustained lung retention (t1/2 = 6.5 h) and high pulmonary levels (>100-fold higher than plasma levels) upon intratracheal administration in rats.
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