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On the other hand, it makes sense to look for variability in care, especially when it involves expensive modalities and does not have obvious impact on outcomes, as these are potentially high yield targets for prospective comparative effectiveness research and reductions in health care expenditures.
There remains a need for prospective randomized trials studying the effectiveness of the PAC, including a strict treatment protocol standardizing therapeutic choices according to PAC derived variables.
This study suggests that prospective comparative effectiveness research [57] is warranted to answer the issues raised.
However, there is also a need for prospective randomised clinical trials with high patient numbers to evaluate the cost-effectiveness of PET/CT.
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Incentives are high for prospective adoptees, too.
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Improvements have been implemented for prospective studies.
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