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Further well-designed human studies are necessary for proper validation.
Despite the fact that 2D-gel technology offers many advantages, one of the pitfalls associated with this technology is the need for several replicates for proper validation of results.
It is like the chicken-egg (catch-22) paradigm: one has to start clinical trials in order to identify the non-responsive patients and only then one can leave them out for proper validation of a new biomarker.
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The reasons for such transformation are due to the need for a proper validation environment for Function Blocks models and the difficulty in obtaining industrial acceptance in this new design approach.
The growing role of 3D modelling of reactor core and Pressure Vessel requires additional experimental data for a proper validation.
For a proper validation of the code, four benchmarks are performed using one-dimensional dynamic analytical solutions developed by the authors.
Indeed, a larger multicenter study will be needed for the proper validation of our current findings.
The acquisition of field datasets comparable with the remote sensing products is also necessary for their proper validation.
The data comparing tumours of different origin suggest that the QLQ-GINET21 can be used for pancreatic as well as non-pancreatic NETs, although it is accepted that pancreatic numbers were too small for a proper validation in patients with this tumour type alone.
The indigenous knowledge of nomads may provide an effective option for veterinary care through proper validation, as also the negligible use of agro-chemicals, especially in drylands and hilly nomadic regions provides a favourable environment for organic livestock production.
In literature, a great diversity of limited sampling strategies (LSS) have been recommended for tacrolimus monitoring, however proper validation of these strategies to accurately predict the area under the time concentration curve (AUC0 12) is limited.
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