Sentence examples for for proper localisation from inspiring English sources
Obviously, the second bromodomain is not essential for proper localisation of tBRD-1.
In mature epithelia, the ERM proteins are largely restricted to the apical domain where they are required for proper localisation and regulation of apical surface proteins, including NHE-RF1 itself (reviewed in Fievet et al, 2007).
Here, we observed shorter microvilli and microvillus inclusion bodies in Rab11a IKO mice (Fig. 4) and showed that Rab11a and Rab8a depend on one another for proper localisation (Fig. 6A,B).
We therefore examined whether Dgp71WD was also required for the proper localisation of bcd.
However, we found that Rab11a is essential for the proper localisation of apical proteins in the intestine (Figs 2, 3).
Dgp71WD is not, however, an essential cofactor for the γ-TuRC, as, in contrast to other γ-TuRC components (Schnorrer et al., 2002; Vogt et al., 2006), it is not required for the proper localisation of bcd mRNA during oogenesis, and a Dgp71WD null mutant is male fertile, unlike γ-TuRC mutants.
For example, glycosylation of GLUT2 is essential for its stability and proper localisation [ 54], and phosphorylation of epidermal growth factor receptor (EGFR) triggers its removal from the plasma membrane by endocytosis, a process known as receptor downregulation [ 55].
Phosphorylation of Ebp1 at Ser 360 is needed for proper nuclear localisation, and for binding ErbB3 and nuclear AKT (Ahn et al, 2006).
Thus, B9d1 is not only required for ciliogenesis in some contexts but also for proper protein localisation to the ciliary compartment.
Characterisation of the RPELMAL G-actin inteRPELMAL G-actinrescence aninteractiond cell reporter-bysed assays validates the signifluorescencectin-binding residues for proper Manisotropyandon and regulation in vivo.
In contrast to Toxoplasma, where ISP1 has been suggested to have a gatekeeping effect by preventing access of ISP3 to the apical end (Beck et al., 2010) we observed that ISP3 is required for proper apical localisation of ISP1.
