Sentence examples for for proper differentiation of from inspiring English sources
Hand is also required for proper differentiation of the wing heart epithelium.
Within the developing retina, precise transcriptional regulation is critical for proper differentiation of specialized subclasses of retinal neurons and glial support cells3.
In the female gonad, FOXL2 is a key factor for proper differentiation of granulosa cells (GC) during folliculogenesis and its expression persists in the ovary after birth.
While the core PRC2 complex proteins are abundantly expressed across all tissues and are required for proper differentiation of embryonic stem cells (ESCs) and somatic stem cells8,9, PRC2 accessory proteins have shown limited expression in certain tissues and hence need to be studied in a tissue-specific manner.
ThPOK preserved the integrity and amplitude of effector responses and was required for proper differentiation of types 1 and 2 helper T cells in vivo by restraining the expression and function of Runx3, a nuclear factor crucial for cytotoxic T cell differentiation.
Yet, it is required for proper differentiation of endothelial cells.
Similarly, Btk is essential for proper differentiation and activation of B-cells [ 36, 37].
It designates the pancreas location in early embryos, and acts as a definitive factor for proper differentiation and maturation of pancreatic β-cells by stimulating insulin gene transcription.
All of these are essential for the proper differentiation of individual neurons and for fine-tuning the details of synaptic connections.
On the other hand, the regulation of the Wnt5 gene through TFs with known implication in pancreas organogenesis, and more specifically in the proper orchestration of cell movements, gives evidence for the necessity of this regulatory module for the proper differentiation of cells capable of producing insulin.
Taken together, analysis of this developmental window (S9-S14) of early human organogenesis and the beyond suggests that the hStemModule may in general reflect the gradual loss of the stem potential, while the hDiffModule reflects the dynamic changes in the differentiation potential that are required for proper differentiation at each stage of this developmental window.
