Gross argues that the seated worker is, essentially, "shackled" to his task and so "in a state of nervous irritation due to forced and prolonged concentration".
Scientists have said that prolonged concentrations over 350 ppm are likely to produce irreversible damage.
And it wouldn't be an exaggeration to say that the ability to maintain concentration for prolonged periods of time is a crucial skill that can be extremely useful both during your studies and throughout your life.
The objective of this research was to demonstrate the possibility of running an MBR with high MLSS concentration for prolonged periods without frequent blocking of the membranes.
On the other hand, anaesthetics at high concentrations for prolonged duration is toxic to the cells and cause cell death via excessive and abnormal calcium release (Wei, 2011).
The goals of these studies have been to predict MTX concentrations at later times or the time that MTX concentrations fall below a threshold value [ 39- 41], MTX dose adjustment [ 42, 43], or providing guidance for rescue administration in the case of elevated MTX concentrations for prolonged time periods [ 44].
Our data show more robust effects when using glucose concentrations as high as 50.5 mM, or with lower concentrations but for prolonged times, which may more closely mimic diabetic pathophysiology.
There is also the potential for prolonged maintenance of elevated Glu concentrations in skeletal muscles to cause desensitization of Glu receptors after ingestion of MSG [14, 15], which might explain why we failed to see an effect of MSG on Glu evoked masseter and temporalis muscle pain.
Recently, Tian et al. [ 42] showed that the CTS/PEG-GA nanoparticles were remarkably targeted to the liver and maintained high concentration of drug for prolonged period of time.
On the contrary, biofilm organisms are tolerant to antimicrobial drugs, disinfectants and biocides [ 38] and high concentrations of antimicrobials for prolonged treatment durations are normally required to achieve biofilm reduction or eradication [ 39].
These concentrations are readily achievable in patients for prolonged time periods using current scheduling and dosing regimens [37].
