In our study, NCOA3 lay just below the threshold for priority candidate disease genes, with nine CAG while priority candidates had ten CAG.
A plot of CAG length versus Q-tract length variance for each target allowed us to identify eight genes as priority candidates for polyglutamine expansion disorders.
As part of its unfolding "green chemistry" program, the state Department of Toxic Substances Control identified three groups of goods as priority candidates for action.
Our data identified several population subsets as priority candidates for possible interventions pursuing this goal.
We propose these genes as priority candidates for functional characterisation to determine their role in chloride transport in grapevine and other plants.
A total of 3,259 unique sequences were found to possess 3,479 SSRs, of which 276 (7.93%) unique sequences annotated in Nr and/or Swissport database were considered as priority candidates for maker development (Table 5, Additional file 3: Table S3).
We assessed these and other observations using GO-based classification of these genes to determine whether specific functional categories are statistically overrepresented, to visualize the network of functional relationships among CAGpolyQ-containing genes, and to determine whether priority candidates for polyglutamine expansion are associated with one or more specific GO terms.
As adaptive genetic variants have been driven to higher frequencies by environmental factors (i.e, positive selection), SNPs showing high FST values may be considered high priority candidates for association studies for gene by environment studies.
As possible sites of allele-specific TF/uDBP binding, such SNPs represent priority candidates for functional studies.
If MRE11 functions to promote release of covalent topoisomerase-DNA complexes independent of its role in DSB repair, MRE11-deficient tumors may be priority candidates for treatment with CPT and ETP derivatives.
Our analyses support these as high priority candidates for therapeutic evaluation in DLBCL alongside PD1 blockade.
