For example, Sanseau and colleagues [ 97] identified registered drugs or drugs in development that target TNFSF11, IL27 and ICOSLG as potential repurposing opportunities for Crohn's disease, given mismatches between GWAS associations with Crohn's involving these genes and current drug indications.
Importantly, some of the undesired side effects are due to drugs not hitting their targets, which can confer potential repurposing opportunities for these drugs and provide novel strategies in drug design.
In the present study, only FDA-approved drugs were considered to be potential repurposing candidates for CF. Moreover, the miRNA-gene-drug relationship was extracted from PharmacomiR [ 62] that provides miRNA pharmacogenomics data manually curated from literatures.
This analysis demonstrates the utility of this process to aid the potential repurposing of drugs for the treatment of different phenotypes (43).
In this work we created RepTB, a GO based DTI network to identify potential repurposed candidates for TB.
In this study, we have developed a drug-repurposing platform, RepTB, using network pharmacology approach to identify potential repurposed candidates for TB.
These interactions are further evaluated based on a combined evidence approach for identification of potential drug repurposing candidates.
Considering the scenario of a patient treated with a particular drug for one indication, it could be observed to have a therapeutic effect for any additional diseases the patient may possess and so present with a potential for repurposing investigations.
Increased knowledge about downstream effects of naturally occurring variation in druggable genes provides important insights into disease mechanisms, predict potential for repurposing drugs and unknown side effects.
While this concept is consistent with previous scientific discussions of the potential for "repurposing" of drugs, the focus on the Ebola virus is very germane to the immediate medical crisis and the need for effective therapies related to Ebola infections.
In addition, we suggest potential alternative repurposing indications for known drugs and chemical tools.
