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Hazard ratios (HR) with 95% CIs for the mortality categories were calculated using Cox proportional hazards regression models, which enabled adjustment for potential confounding parameters.
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Additionally, to adjust better for the severity of disease, the length of stay and device use (use of central venous catheters and ventilation per 100 pd) were considered as potential confounding parameters in the model.
Potential confounding parameters, such as opposite cortex fractures, demographic data, length, weight and BMI will be recorded.
In crude analyses and after statistical adjustments for potential confounding baseline parameters and the time-dependent DAS28ESR or cDAI, anaemic patients experienced significantly faster radiographic progression (p<0.001) than their non-anaemic counterparts, irrespective of the employed anaemia definition (figure 1).
Multivariable analysis adjusting for potential confounding factors of (1) resting parameters (E/E′, diastolic dysfunction grading, GLS) and (2) stress parameters (DFRI and stress GLS) is shown in Additional file 1: Tables S1 S5.
These variables were used as confounders to control for potential confounding.
Aggregate scores have the advantage of summarizing the risk of the outcome attributable to a particular set of covariates into one summary measure, thereby reducing the number of parameters to be estimated while still controlling for potential confounding effects.
Correlations between insulin/IGF-I system parameters were presented as Spearman correlation coefficients and partial correlation coefficients adjusted for potential confounding variables.
All included studies adjusted for potential confounding covariates.
Additionally, future studies should control for potential confounding factors.
Notably, prior studies have not consistently controlled for potential confounding by psychological or anatomical factors.
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