Circuits of reciprocally connected neurons have been long considered as a basis for themaintenance of persistent activity [1].
This work indicated that synaptic augmentation can reduce the amount of prior structure required for persistent activation to take place, while rapid Hebbian plasticity could enable persistent activity to take place within firing rate ranges observed in real cortical neurons.
We found no evidence for the involvement of D2-like receptors in the dopamine-mediated suppression of persistent activity.
Guo, Z. V. et al. Maintenance of persistent activity in a frontal thalamocortical loop.
Beyond working memory: the role of persistent activity in decision making.
Brody, C. D., Romo, R. & Kepecs, A. Basic mechanisms for graded persistent activity: discrete attractors, continuous attractors, and dynamic representations.
One likely reason for the persistent activity of PI3K signaling is homozygous mutation of PTEN in LNCaP cells leading to the lack of its expression in this system [26].
BDNF has been found to play a role in the late phase of asthma [ 14], and has been reported to be involved in the infiltration of eosinophils, which are known for their persistent activity in asthma, into the lungs [ 11]. p75NTR knockout mice are known to have a lower response to allergic stimulation [ 20].
... Collectively, our results pinpoint to specific features of the neuronal response to a given stimulus that code for its ability to induce persistent activity and predict differential roles of RS and IB neurons in persistent activity expression.
TRPC5 channels a) are one of the two most prevalent TRPC channels in the adult rodent brain ; b) are densely expressed in deep layer pyramidal neurons of the PFC ; and c) modulate neuronal persistent activity necessary for working memory and attention.
