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Use of perforin-deficient pfpCTLs and Fas-resistant CT26 tumor cells will eliminate the function of perforin and Fas/FasL effector mechanisms of the CTLs, thus reducing the CTL cytotoxicity background for optimal TRAIL function evaluation.
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However, cells transfected with dnTCF4 reproducibly showed a modestly reduced amount of TRAIL-induced apoptosis (differences were not statistical significant), which may be consistent with the requirement of the Wnt pathway for optimal TRAIL-induced apoptosis [32] (Fig. 5A).
Therefore, additional research is needed to identify factors that determine the optimal TRAIL variant (or antibody) on a case-by-case basis for each individual tumour.
In this term, to refer to the semi-optimal trail structure and address the deviation in the trail system for the compound topology of nodes, they employed the term of "pro-Steiner" structure and deviation.
Two agonistic receptors for TRAIL, TRAIL-R1 (DR4) and TRAIL-R2 (DR5, KILLER), and two antagonistic receptors, TRAIL-R3 (DcR1) and TRAIL-R4 (DcR2), have been identified (Ashkenazi and Dixit, 1999).
This motivates us to formulate a new suite of ILPs (Integer Linear Programs) for optimal design of non-simple p-cycles and p-trails, based on which the achievable capacity gain over simple p-cycles can be investigated.
To site it for optimal views, they sculpted the land.
Hardly anyone on the planet eats for optimal health.
He was largely responsible for using the twin instruments together for optimal results.
True for minimal results; false for optimal results.
for optimal learning and for their own enjoyment.
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