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Patients were evaluated for objective response every two cycles.
Assessment for objective response was carried out every three cycles.
Patients were assessed for objective response by the UICC criteria.
Detailed results for objective response and resectability after CRT are summarised in Table 2. Overall, 70 patients were evaluable for objective response according to WHO criteria.
Patient recruitment was outlined as a total of 30 patients evaluable for objective response.
Of the 41 patients treated with afatinib, 35 patients were evaluable for objective response (Table 2).
Similar(28)
A Box-Behnken design was used to produce models for objective responses based on parameters that have significant probabilities.
In our dose-finding study, evidence is presented for objective responses in patients treated with the higher dose of sunitinib 37.5 mg per day in combination with irinotecan.
Of the 25 patients assessable for objective responses, there was evidence for modest antitumor activity (PR = 2 patients, SD > 6 months = 13, SD < 6 months = 4 and progressive disease (PD) = 6).
With 87 patients enrolled, the statistical power for the objective response rate was 24%, and for the R0 resection rate 32%.
Two-sided Clopper Pearson confidence intervals for the objective response rates were calculated and adjusted for the two-stage design utilized in the study.
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