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There is increasing evidence for nuclear dysfunction in neurodegenerative diseases.
For most neurodegenerative diseases, evidence for nuclear dysfunction, with attendant consequences for nuclear architecture, is only beginning to emerge.
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In this review, I will discuss neurodegenerative diseases in the context of nuclear dysfunction and, more specifically, alterations in nuclear bodies.
If nuclear dysfunction represents an important etiopathological feature in neurodegenerative disease, then this should be reflected by functional and/or morphological alterations in this nuclear compartmentalization.
This suggests that, in somatic cells, LB1 overexpression causes biophysical changes in the nuclear lamina that alter nuclear signaling, possibly leading to nuclear dysfunction in ADLD.
Thus, it would be important whether the CTF may lead to nuclear dysfunction.
However, when visualized by fluorescence microscopy with Hoechst and propidium iodide a nuclear dysfunction is evident.
Mitochondrial and nuclear dysfunction and increased oxidative stress contribute to the onset of replicative senescence.
Is this good news for nuclear power?
You need roots for nuclear DNA.
Lastly, DAPI was used for nuclear staining.
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