Sentence examples for for normal repair from inspiring English sources

Given that a subset of CCSP expressing epithelial cells have been implicated to function as progenitor cells critical for normal repair of the lower airway epithelium, the sustained depletion of these cells, in particular, could contribute to disease pathogenesis [22].

Moreover, it is possible that some of these mechanisms, activated early in the response to injury, are essential for normal repair later on.

Complementation with the exonuclease/helicase double mutant or wild-type WRN restores NHEJ activity, suggesting that WRN is necessary for normal repair of DSBs (Chen et al 2003).

Previous studies have indicated that small amounts of MLH1 are enough for normal repair of microsatellites, whereas much higher levels of this protein are required for damage signalling to be functional (Buermeyer et al, 1999; Cejka et al, 2003).

However, prolonged and/or significantly increased expression of activin may lead to involved the development of fibrosis, thus a tight control of activin level is likely to be important for normal repair[ 73].

The current line of investigations suggests that p38 MAPK and JNK activity could be associated with MMP-mediated irreversible cartilage damage, whereas the processes needed for normal repair mechanism and aggrecanase activity may in part be controlled by MAPK p44/42-activities p44/42-activities

Thus, ubiquitination is necessary for hyper-recombination in the context of altered BRCT interactions to compensate for the loss of normal repair activity associated with BRCA1 complexes.

This demonstrated that endogenous TGF-beta was required for a normal repair response and that lack thereof aggravates cartilage damage.

Although this pathway has been shown to be critical for a normal repair phenotype, even a hepatocyte-specific STAT-3 knockout does not completely inhibit regeneration [ 36].

The enzyme PLAU is required for the normal repair of wounds originating on skin [ 104] and, as stated earlier, S. uberis can activate the conversion of PLAU to plasmin [ 23].

It has been hypothesized that PLA2G6 is critical for the normal repair and remodelling of damage to cardiolipin caused by mitochondrial reactive oxygen species, and that loss of PLA2G6 activity may lead to cardiolipin oxidation and pathogenic downstream events such as induction of apoptosis.