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Inhibiting FASN leads to tumor cell death while sparing normal cells, which do not have the dependence of this enzyme for normal functions, and restores membrane architecture to more normal properties thereby resensitizing tumors to killing by chemotherapies.
Since head and neck cancer (HNC) affects structures that are critical for normal functions such as speech and swallowing, and treatment may lead to deformities that adversely impact psychosocial functioning, there is particular interest in assessing QOL in this cohort of patients.
With Cre recombinase expression directed by a glucagon promoter in α-cells or an insulin promoter in β-cells, we showed that deletion of Vhl is dispensable for normal functions of the endocrine pancreas.
However, excessive compensation might not always be beneficial for normal functions.
COX-1 is constitutively expressed in most tissues and considered to generate prostaglandins for normal functions (Liu and Rose, 1996).
Secondly, the mechanical force-induced signal transduction by injurious ventilation (high tidal volume and high oxygen tension) could activate pathways that are important for normal functions.
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The proteins controlled by these genes serve as damage detectors, regulating healthy cell proliferation and blocking the action of other proteins required for normal function.
They then awaken the patient, and probe the area around the tumor to see exactly which parts of the brain are crucial for normal functioning.
This was defined as the upper limit for normal function.
Manganese (Mn) is an essential trace element required for normal function and development.
Ratio of low density to high density lipoprotein concentration is critical for normal functioning of human body.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com