In this study, we took a multi-level functional genomics approach to identify kinases required for normal function of individual and multiple processes within a single tissue in vivo.
The proteins controlled by these genes serve as damage detectors, regulating healthy cell proliferation and blocking the action of other proteins required for normal function.
This was defined as the upper limit for normal function.
Manganese (Mn) is an essential trace element required for normal function and development.
Specific roles for each of the ERs in the ovary have yet to be established, despite ER knockout studies indicating both are required for normal function.
Various biomechanical and cadaver studies have demonstrated the role of fibula in weight transmission and for normal function of the knee and ankle [13, 14, 15, 16, 17].
However, it is notable that, in ribosomal RNA, many of the post-transcriptional modifications occur in highly functional regions, such as the peptidyl transferase center and the subunit interface, implying that they are important for normal function.
Accurate and timely flow of information through messenger proteins, often in multi-protein complexes, from the cell membrane (CM) to the nucleus is necessary for normal function [5].
Cycles of neddylation and deneddylation of Cullins are thought to be required for normal function of Cullin-based ubiquitin ligases [13], [21].
Intracellular transport of cargoes including organelles, vesicles, signalling molecules, protein complexes, and RNAs, is essential for normal function of eukaryotic cells.
Many of these residues are conserved in a wide variety of myosin II isoforms, suggesting that they may be important for normal function of the molecule.
