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For normal bone growth, physiological load is required (Malina 1969).
For normal bone, osteoblast (OB) number and osteoclast (OCL) number at the bone surface were measured in the distal femur and proximal tibia at 200×magnification on H&E and TRAP stained slides, respectively.
Vitamin D, essential for normal bone and teeth development and kidney function, is formed in the skin of animals after exposure of the chemical 7-dehydrocholesterol to sunlight.
ALPL is a late osteogenic marker, which is essential for normal bone mineralization.
The aim of this study was to determine whether locally produced PAPP-A2 is required for normal bone growth.
Recent studies with osteoclast deficient animal models have definitely revealed that the regulatory effect of osteoclasts is essential for normal bone formation.
Some physiological load is needed for normal bone growth, [[2]] but exceeding this physiological load can lead to unwanted morphological changes and different pathologies of the bone and joints [[3],[4]].
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Those effects appeared more pronounced for the reduced than for the normal bone stock model.
The average CD22ΔE12 index values were − 0.15 ± 0.03 for the leukemia samples and 0.52 ± 0.07 for the normal bone marrow samples (Fig. 1A).
The response of osteoprogenitors to calcium (Ca2+) is of primary interest for both normal bone homeostasis and the clinical field of bone regeneration.
Osteoclasts (OCs) are the only cells capable of bone resorption, a process required for both normal bone homeostasis and pathological bone loss [1].
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