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The p values adjusted for multiple testing was calculated using the Benjamini-Hochberg procedure, which controls false discovery rate (FDR).
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To correct for multiple testing, a q value was calculated using the QVALUE software package (Storey and Tibshirani 2003) for each test.
The Bonferroni-Šidák significance threshold for multiple tests in the FABP3 region was calculated using alpha = 0.05 (significant) and alpha = 0.1 (suggestive), and the effective number of tests.
For multiple group comparison, significant difference was calculated using the non-parametric Mann-Whitney U test.
*Multiple testing corrected P value; P ACT (P values adjusted for correlated tests) within each gene was calculated using the methods by Conneely and Boehnke [ 33]. † P values for interaction were not corrected for multiple testing.
Multiple testing corrected P value; P ACT (P values adjusted for correlated tests) within each gene was calculated using the methods by Conneely and Boehnke [ 33].
Agreement beyond chance between assessors was calculated using kappa's coefficient for multiple observers and multiple test results.
False discovery rate (FDR) correction was calculated using Benjamini and Hochberg multiple testing correction [ 23].
Statistical enrichment was calculated using a systematic hypergeometric test across protein families, following correction for multiple testing with the Benjamini Hochberg method.
Differential expression was calculated using LIMMA v3.6.0, P-values were corrected for multiple testing and probes with P<0.01 were deemed significant.
Note: p value was calculated using the Benjamini-Hochberg method of multiple testing correction.
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