The capability to engineer microenvironmental cues to direct a stem cell population toward multiple fates, simultaneously, in spatially defined regions is important for understanding the maintenance and repair of multi-tissue units.
In vivo, stromal cells form a complex microenvironment for HSCs that controls their multiple fates, including apoptosis, migration, and the cell divisions that lead to formation of lineage-committed progenitors [ 31, 32].
In vivo, stromal cells and other cells form a complex microenvironment for HSCs that controls their multiple fates, including quiescence, apoptosis, and migration as well as the cell divisions that lead to formation either of daughter HSCs or of lineage-committed progenitors that are capable of limited proliferation.
Human memory CD4+ T cells acquire multiple fates when responding to infection or vaccination.
Accumulating evidence using various lines of genetic cell-fate mapping mice reveals multiple fates of NG2 cells in vivo.
Our observations showed that once a nascent branch forms, it can have multiple fates.
This approach presents a powerful new methodology for controlling cell fate, and is promising for multiple applications in tissue engineering and regenerative medicine.
This study reveals essential roles of Nf1 in GC/UBC migration by generating correct numbers of glia and controlling GC/UBC fate-specification/differentiation, identifying a therapeutic prevention strategy for multiple NF1-associcated developmental abnormalities.
"It may be for multiple reasons".
Of course, art allows for multiple readings.
Billboards advertise volume discounts for multiple purchases.
