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In the recently proposed framework for model qualification of physiological models, the first step frames the project questions and the project team agrees on the use of the model inferences for the decision making.
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The objective of model qualification is to examine whether the model is suitable for the proposed applications.
As a second level of model qualification, we tested the sensitivity of the system-specific parameters for both models (EPIC 1 and EPIC 2).
CoSMoS, the principled design framework used in the development of ARTIMMUS, for example, shares many key features with the methods for physiological model qualification in drug discovery proposed by Friedrich and Savic.
For plasma PK profiles and urinary metabolite ratios, model qualification was performed by comparing population mean or individual values of the observations with the model predictions.
This approach is not different from an earlier proposed general model qualification method to ensure that physiological models are fit for purpose.
Details of the flight model qualification test program are presented.
Model qualification.
JM created the methotrexate population pharmacokinetic model, provided model qualification and created the forecasting algorithm.
A chamber for testing solar cells and other devices in a simulated space environment, and the integration and tests of two engineering models for qualification of space technology processes are described.
Figures 4 (men) and 5 (women) present the δj coefficients from this model for each qualification group.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com