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The nutritional questionnaire was first screened for missing responses and those questionnaires with more than 10 missing responses in the food and beverage section were excluded.
No imputation was performed for missing responses.
Through simulation, we show that imputation for missing responses under this adaptive design set-up has a clear gain over the method that uses only complete data.
To address issues of unequal probabilities of selection and modification for missing responses, appropriate weight variables (i.e., wtmec2yr, sdmvstra, and sdmvpsu) were used in all statistical analyses.
¥Trust score transformed and weighted for missing responses.
We created an indicator variable for missing responses in each covariate.
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The data from two published demonstration studies were used for missing response analysis and criterion validation.
This might have been a reason for missing response, as EGFR protein expression observed by IHC has been described as an unreliable predictor of responsiveness to EGFR inhibitors (Ciardiello and Tortora, 2008; Vidal et al, 2009).
We were not able to detect any parameter that seemed to be responsible for missed response detection.
There is also a small increase in the percentage of missing responses for Ireland in position 1.
The high frequency of missing responses for specific questions precluded generation of multivariate models.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com