Sentence examples for for miRNA repression from inspiring English sources

It has been well documented that the 5′ cap is important for miRNA repression.

Here we confirmed their result that eIF4E2 is required for miRNA repression of target mRNA translation.

While the 5′ 7-methylguanosine cap of target mRNAs has been well known to be important for miRNA repression, the underlying mechanism is not clear.

It has been extensively reported that the 5′ cap of target mRNA is important for miRNA repression (Pillai et al., 2005; Mathonnet et al., 2007; Humphreys et al. 2005; Walters et al., 2010).

Both RB and E2F are targets for miRNA repression, including miR-17, miR-20, miR-34, miR-93, miR-106, miR-205, and miR-331 (Dar et al. 2011; Guo et al. 2010b; Tazawa et al. 2007; Trompeter et al. 2011) whose expression is dysregulated in genotoxic drug resistance (Kovalchuk et al. 2008; Pogribny et al. 2010).

These findings highlight the relevance of the transient relief of miRNA repression for macrophage function.

Although there are tissue-specific signatures of miRNA repression or miRNA mRNA mutual-exclusiveness for several highly expressed miRNAs, the pattern of miRNA target gene expression is complicated, especially in the central nervous system (CNS) [2], [15] [16].

There is increasing evidence indicating that translation initiation is the major target of miRNA repression.

The results collectively confirmed that both the cap and 5′UTR are targets of miRNA repression (Fig. 1).

This notion was further supported by the observation that the cap-binding activity of eIF4E2 was required for optimal miRNA repression (Fig. 6).

We wished to determine whether Dcp2 is also required for the miRNA repression observed in the Drosophila eye.