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References for maximum lifespan, body mass and age at sexual maturity are given in Table S7 and Supporting References S1.
We detected a clear difference in age-dependent cognitive decline and a slight difference in lifespan (16% for median, 15% for maximum lifespan) between these lines.
The full equation (2.3 a) can be seen as (2.4), corrected for maximum lifespan and population growth.
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Diagnostic tests identified the sperm whale pair, Kogia breviceps- Physeter catodon, as a weak outlier, and excluding this pair increases the r 2 to levels matching those in Table 2. (It is possible that the outlying nature of this point reflects the recognised difficulties obtaining accurate measurements of maximum lifespan for cetaceans: [ 47].) Note:- * p < 0.05, ** p < 0.005.
The deletion of one SIRT1 allele resulted in a trend for decreased maximum lifespan under CR conditions (Fig. 1A).
The analysis showed that, for example, maximum lifespan strongly covariates with body weight (r = 0.47, P = 4 × 10−113, F-test), time to maturity (r = 0.71, P = 1 × 10−156, F-test), and other examined traits (Fig. 2).
The age at maturity is around four years for males and six years for females; the maximum lifespan is at least 12 years for males and 16 years for females.
In order to test for differences in maximum lifespan between experimental groups, the 90th percentile of overall survival time when all groups were combined were calculated.
The Wang Allison test (Wang et al., 2004) for differences in maximum lifespan was implemented in R. SurvCurv uses the Cox proportional hazards model implementation of the survival package with the Efron approximation for ties.
Wang et al. also showed that a commonly used test for differences in maximum lifespan that involved comparing the means of the top p% (e.g., top 10%) of each of two samples (e.g., a treatment and a control sample) was not valid in that it had an excessive type-1 error rate.
The mean lifespan was 11 weeks (w) for GRZ and 30 w for MZM-0403, and the maximum lifespan values (maximum values always refer to 10% survivorship) were 16 w and 53 w, respectively, which were significantly different (P < 0.001, log-rank test).
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