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DNA methylation is essential for mammalian development.
Thus, while individual CDKs are dispensable for mammalian development, they have cell type-specific functions [7].
AIF is essential for mammalian development, knocking out AIF in the mouse is lethal before birth [12].
Since neither Rpn13 nor Uch37 is an integral proteasomal subunit, we explored whether either protein is essential for mammalian development and survival.
These data validate the power of ESC differentiation strategies as a model for mammalian development and, in combination with established genomic technologies, as a powerful gene discovery tool for developmental processes.
It is important for mammalian development and embryonic growth.
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Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hIPSCs) offer unique opportunities for regenerative medicine and for the study of mammalian development.
Sox2 is a high mobility group transcription factor essential for early mammalian development and for the maintenance of both pluripotential embryonic stem cells and stem cells in multiple adult tissues [1], [2], [3], [4], [5].
The regulation of apoptosis under basal (non-stress) conditions is crucial for normal mammalian development and also for normal cellular turnover in different tissues throughout life.
The programmed regulation of apoptosis under basal physiological conditions is crucial for normal mammalian development and, in the adult, for normal cellular turnover in individual tissue types.
Here we show for the first time that a mammalian histone variant, H2A.Z, plays a critical role in early development, and we conclude that this histone variant plays a pivotal role in establishing the chromatin structures required for the complex patterns of gene expression essential for normal mammalian development.
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