Our work clearly demonstrates that TDU was the major uptake mechanism for cationic particles, especially for DLS and Nx+ in OptiMEM (62 and 66%, respectively for 3 and 6 h) like in previous studies [12] [15].
Breast milk, as Smolders et al. [ 11] observe: "is a major uptake route for environmental contaminants and represents the main exposure source for breast feeding infants".
In the lactation period, human milk is a major uptake route for environmental contaminants due to its fatty character, especially for primigravidae mothers [ 15, 16].
The fact that the pyoverdine receptor FpvA, the major uptake system for iron in P. aeruginosa [48], [56], is amongst these mutants, is consistent with this interpretation.
We now identified VRAC as a major uptake mechanism for cis- and carboplatin.
The fish gill provides an elegant experimental system for studying mineral absorption in vivo since the concentration and speciation of metal ions on the apical side can be carefully controlled, and this organ provides the major uptake pathway for ions, including zinc [ 35].
Trophic transfer of Hg from algae added to the water column was determined to be the major uptake route for amphipods, suggesting inputs of contaminated organic matter from the pelagic zone are important to mercury bioaccumulation even in organisms living in sediments.
Importantly, however, the fact that inhibition of three major uptake routes did not drastically impair PrPSc uptake strongly argues that prions can enter cells by multiple pathways, as has been documented for other pathogens63.
The major uptake is displayed by the HAs sample.
These dating sites have witnessed major uptakes over the last couple of years because of the races for the nominations and the eventual presidential race.
