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Hemodiafiltration recipients received higher doses, except in three trials where doses in the two treatment arms were similar, although not corrected for lower clearance due to pre-filter addition of replacement fluid [ 23, 27, 29].
Similar(59)
No difference in the likelihood of clearance was observed by HPV type or woman's age, with the exception of lower clearance for HPV16 infection in women under 30 years of age.
For the lower clearance heights, the plastic strain in the CL is reduced due to reduction of the in-plane swelling ratio of the NR211 as it swells.
CYP3A4*22 carriers showed a significant lower clearance for cyclosporine (−15%), and a trend was observed for everolimus (−7%) and tacrolimus (−16%).
In the experiment, for example, some healthy subjects had lower clearance rates than average for their group, close to or slightly within the range seen in Alzheimer's patients.
A significant association between C1236T polymorphism and docetaxel clearance was reported by Bosch et al (2006), as patients homozygous for the variant T allele showed lower clearance.
This is because a unique and single dosing regimen in any adult (i.e. 1 g intravenous paracetamol, q6h for maximal 48 hours) irrespective of other covariates may be an over-simplification, omitting clinical settings with either higher (insufficient effect) or lower clearance (raised risk for toxicity).
As a strong cytochrome P450 3A4 inhibitor, LPT might be responsible for an unfavourable modulation of VNR with a lower clearance inducing higher myelosuppression.
"Cognitive tests show no signs of dementia in these participants now, but we'll be interested to see if a lower clearance rate is a predictive marker for future diagnosis of Alzheimer's disease," said Bateman.
The lower clearance rate and higher exposure dose of Asp-DOX were necessary for its accumulation in tumor sites to exert its potent effect.
Both lower clearance ratio and lower inter-fin spacing ratio and comparatively lower Reynolds numbers are suggested for higher thermal performance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com