The mesolimbic dopamine system, specifically dopaminergic projections from the ventral tegmental area (VTA) to the nucleus accumbens (NAc), has been studied extensively for its role in mediating the rewarding effects of drugs of abuse and may be responsible for mediating the differences in motivation seen in the bHR and bLR animals.
Phosphorylated H2AX, also called γH2AX, is well known for its role in mediating DNA damage response39,40.
Skidmore Owings & Merrill, which is expected to take the lead role in the project, is highly valued for its skill in mediating with these groups.
During a trip to [a southern city] … I visited a local community that had gained some national renown for its success in mediating disputes.
PGE2 signals through four G-protein-coupled receptors, including the EP2 receptor that has been investigated for its role in mediating the inflammatory and phagocytic responses to Aβ [4].
With respect to its cell specific effects, HIF, in addition to activating downstream target genes that increase oxygen delivery, acts on the vascular endothelial growth factor (VEGF), well known for its role in mediating angiogenesis, but furthermore exhibiting critical impact on epithelial cell survival and differentiation, thereby influencing surfactant production [17].
[The original AP story is still visible here.] U.S. officials have dismissed the deal brokered by Brazil and Turkey, even though the deal is "nearly identical" to the one proposed by the U.S. Indeed, according to the Washington Post, U.S. officials are "thoroughly irritated" with Turkey for its role in mediating the agreement.
Misregulation of the AMPK-mTOR pathway likely contributes to LKB1's role as a tumor suppressor, but probably does not entirely account for its role in mediating invasion [31].
The piRNA machinery is known for its role in mediating epigenetic silencing of transposons.
